Ontology highlight
ABSTRACT:
SUBMITTER: Schreck C
PROVIDER: S-EPMC5206491 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20161220 1
Here, we show that the Wnt5a-haploinsufficient niche regenerates dysfunctional HSCs, which do not successfully engraft in secondary recipients. RNA sequencing of the regenerated donor Lin<sup>-</sup> SCA-1<sup>+</sup> KIT<sup>+</sup> (LSK) cells shows dysregulated expression of ZEB1-associated genes involved in the small GTPase-dependent actin polymerization pathway. Misexpression of DOCK2, WAVE2, and activation of CDC42 results in apolar F-actin localization, leading to defects in adhesion, mig ...[more]