Neutrophils induce proangiogenic T cells with a regulatory phenotype in pregnancy.

ABSTRACT: Although neutrophils are known to be fundamental in controlling innate immune responses, their role in regulating adaptive immunity is just starting to be appreciated. We report that human neutrophils exposed to pregnancy hormones progesterone and estriol promote the establishment of maternal tolerance through the induction of a population of CD4⁺ T cells displaying a GARP⁺CD127^loFOXP3⁺ phenotype following antigen activation. Neutrophil-induced T (niT) cells produce IL-10, IL-17, and VEGF and promote vessel growth in vitro. Neutrophil depletion during murine pregnancy leads to abnormal development of the fetal-maternal unit and reduced empbryo development, with placental architecture displaying poor trophoblast invasion and spiral artery developm

SUBMITTER: Nadkarni S 

PROVIDER: S-EPMC5206541 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature