Identification of genetic susceptibility loci for intestinal Behcet's disease.

ABSTRACT: Several recent genome-wide association studies (GWAS) identified susceptibility loci/genes for Behçet's disease (BD). However, no study has specifically investigated the genetic susceptibility loci associated with intestinal involvement in BD. We aimed to identify distinctive genetic susceptibility loci/genes associated with intestinal involvement in BD and determine their roles in intestinal inflammation as well as their interactions with genes involved in inflammatory bowel disease (IBD). GWAS and validation studies showed intestinal BD-specific associations with an NAALADL2 gene locus (rs3914501, P = 3.8 × 10^-4) and a YIPF7 gene locus (rs6838327, P = 3.5 × 10^-4). Validation, haplotype, and pathway analyses showed distinct genetic architectures between intestinal BD

SUBMITTER: Kim SW 

PROVIDER: S-EPMC5206652 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature