EColiCore2: a reference network model of the central metabolism of Escherichia coli and relationships to its genome-scale parent model.

ABSTRACT: Genome-scale metabolic modeling has become an invaluable tool to analyze properties and capabilities of metabolic networks and has been particularly successful for the model organism Escherichia coli. However, for several applications, smaller metabolic (core) models are needed. Using a recently introduced reduction algorithm and the latest E. coli genome-scale reconstruction iJO1366, we derived EColiCore2, a model of the central metabolism of E. coli. EColiCore2 is a subnetwork of iJO1366 and preserves predefined phenotypes including optimal growth on different substrates. The network comprises 486 metabolites and 499 reactions, is accessible for elementary-modes analysis and can, if required, be further compressed to a network with 82 reactions and 54 metabolites having an identical solu

SUBMITTER: Hadicke O 

PROVIDER: S-EPMC5206746 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature