Slamf6 negatively regulates autoimmunity.

ABSTRACT: The nine SLAM family (Slamf) receptors are positive or negative regulators of adaptive and innate immune responses, and of several autoimmune diseases. Here we report that the transfer of Slamf6^-/- B6 CD4⁺ T cells into co-isogenic bm12 mice causes SLE-like autoimmunity with elevated levels of autoantibodies. In addition, significantly higher percentages of Tfh cells and IFN-γ-producing CD4⁺ cells, as well as GC B cells were observed. Interestingly, the expression of the Slamf6-H1 isoform in Slamf6^-/- CD4⁺ T cells did not induce this lupus-like phenotype. By contrast, Slamf1^-/- or Slamf5^-/- CD4⁺ T cells caused the same pathology as WT CD4⁺ T cells. As the transfer of Slamf [1+6]^-/-

SUBMITTER: Wang N 

PROVIDER: S-EPMC5206809 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature