Targeting pediatric versus elderly populations for norovirus vaccines: a model-based analysis of mass vaccination options.

ABSTRACT:

Background

Noroviruses are the leading cause of acute gastroenteritis and foodborne diarrheal disease in the United States. Norovirus vaccine development has progressed in recent years, but critical questions remain regarding which age groups should be vaccinated to maximize population impact.

Methods

We developed a deterministic, age-structured compartmental model of norovirus transmission and immunity in the U.S.

Population

The model was fit to age-specific monthly U.S. hospitalizations between 1996 and 2007. We simulated mass immunization of both pediatric and elderly populations assuming realistic coverages of 90% and 65%, respectively. We considered two mechanism of vaccine action, resulting in lower vaccine efficacy (lVE) between 22% and 43% and higher VE (hVE)

SUBMITTER: Steele MK 

PROVIDER: S-EPMC5206891 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature