Associations between actigraphy-assessed sleep, inflammatory markers, and insulin resistance in the Midlife Development in the United States (MIDUS) study.

ABSTRACT:

Background

Disturbed sleep has been associated with increased insulin resistance and elevated inflammation. Although there is growing body of evidence that activation of inflammatory pathways plays a crucial role in the development of insulin resistance, the mediational model whereby sleep disturbances influence inflammation that drives insulin resistance has not been fully assessed in general population studies with objectively measured sleep. This study aimed to examine associations between objectively measured sleep, inflammatory markers, and insulin resistance simultaneously and in a mediational analysis, thereby offering insights into the possible causal model.

Methods

Cross-sectional data collected from 2004 to 2009 during the Midlife Development in the United States I

SUBMITTER: Kim TH 

PROVIDER: S-EPMC5206915 | biostudies-literature | 2016 Nov - Dec

REPOSITORIES: biostudies-literature