Gα13 Switch Region 2 Relieves Talin Autoinhibition to Activate αIIbβ3 Integrin.

ABSTRACT: Integrins function as bi-directional signaling transducers that regulate cell-cell and cell-matrix signals across the membrane. A key modulator of integrin activation is talin, a large cytoskeletal protein that exists in an autoinhibited state in quiescent cells. Talin is a large 235-kDa protein composed of an N-terminal 45-kDa FERM (4.1, ezrin-, radixin-, and moesin-related protein) domain, also known as the talin head domain, and a series of helical bundles known as the rod domain. The talin head domain consists of four distinct lobes designated as F0-F3. Integrin binding and activation are mediated through the F3 region, a critically regulated domain in talin. Regulation of the F3 lobe is accomplished through autoinhibition via anti-parallel dimerization. In the anti-parallel dimerizati

SUBMITTER: Schiemer J 

PROVIDER: S-EPMC5207171 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature