DNA micelle flares: a study of the basic properties that contribute to enhanced stability and binding affinity in complex biological systems.

ABSTRACT: DMFs are spherical DNA-diacyllipid nanostructures formed by hydrophobic effects between lipid tails coupled to single-stranded DNAs. Such properties as high cellular permeability, low critical micelle concentration (CMC) and facile fabrication facilitate intracellular imaging and drug delivery. While the basic properties of NFs have been amply described and tested, few studies have characterized the fundamental properties of DMFs with particular respect to aggregation number, dissociation constant and biostability. Therefore, to further explore their conformational features and enhanced stability in complex biological systems, we herein report a series of characterization studies. Static light scattering (SLS) demonstrated that DMFs possess greater DNA loading capacity when compared to oth

SUBMITTER: Wang Y 

PROVIDER: S-EPMC5207227 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature