The Aspergillus fumigatus SchA^SCH9 kinase modulates SakA^HOG1 MAP kinase activity and it is essential for virulence.

ABSTRACT: The serine-threonine kinase TOR, the Target of Rapamycin, is an important regulator of nutrient, energy and stress signaling in eukaryotes. Sch9, a Ser/Thr kinase of AGC family (the cAMP-dependent PKA, cGMP- dependent protein kinase G and phospholipid-dependent protein kinase C family), is a substrate of TOR. Here, we characterized the fungal opportunistic pathogen Aspergillus fumigatus Sch9 homologue (SchA). The schA null mutant was sensitive to rapamycin, high concentrations of calcium, hyperosmotic stress and SchA was involved in iron metabolism. The ΔschA null mutant showed increased phosphorylation of SakA, the A. fumigatus Hog1 homologue. The schA null mutant has increased and decreased trehalose and glycerol accumulation, respectively, suggesting SchA performs different roles for gl

SUBMITTER: Alves de Castro P 

PROVIDER: S-EPMC5207228 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature