Similarity and diversity of translational GTPase factors EF-G, EF4, and BipA: From structure to function.

ABSTRACT: EF-G, EF4, and BipA are members of the translation factor family of GTPases with a common ribosome binding mode and GTPase activation mechanism. However, topological variations of shared as well as unique domains ensure different roles played by these proteins during translation. Recent X-ray crystallography and cryo-electron microscopy studies have revealed the structural basis for the involvement of EF-G domain IV in securing the movement of tRNAs and mRNA during translocation as well as revealing how the unique C-terminal domains of EF4 and BipA interact with the ribosome and tRNAs contributing to the regulation of translation under certain conditions. EF-G, EF-4, and BipA are intriguing examples of structural variations on a common theme that results in diverse behavior and function. S

SUBMITTER: Ero R 

PROVIDER: S-EPMC5207388 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature