Transcriptional and Post-Transcriptional Regulation of Thrombospondin-1 Expression: A Computational Model.

ABSTRACT: Hypoxia is an important physiological stress signal that drives angiogenesis, the formation of new blood vessels. Besides an increase in the production of pro-angiogenic signals such as vascular endothelial growth factor (VEGF), hypoxia also stimulates the production of anti-angiogenic signals. Thrombospondin-1 (TSP-1) is one of the anti-angiogenic factors whose synthesis is driven by hypoxia. Cellular synthesis of TSP-1 is tightly regulated by different intermediate biomolecules including proteins that interact with hypoxia-inducible factors (HIFs), transcription factors that are activated by receptor and intracellular signaling, and microRNAs which are small non-coding RNA molecules that function in post-transcriptional modification of gene expression. Here we present a computational mod

SUBMITTER: Zhao C 

PROVIDER: S-EPMC5207393 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature