Recent Progress in Understanding the Conformational Mechanism of Heterotrimeric G Protein Activation.

ABSTRACT: Heterotrimeric G proteins are key intracellular coordinators that receive signals from cells through activation of cognate G protein-coupled receptors (GPCRs). The details of their atomic interactions and structural mechanisms have been described by many biochemical and biophysical studies. Specifically, a framework for understanding conformational changes in the receptor upon ligand binding and associated G protein activation was provided by description of the crystal structure of the β2-adrenoceptor-Gs complex in 2011. This review focused on recent findings in the conformational dynamics of G proteins and GPCRs during activation processes.

SUBMITTER: Duc NM 

PROVIDER: S-EPMC5207459 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature