Effect of vitamin D3 on self-perceived fatigue: A double-blind randomized placebo-controlled trial.

ABSTRACT:

Background

Vitamin D deficiency is frequent and has been associated with fatigue in uncontrolled trials.

Methods

This is the first double-blind placebo-controlled clinical trial to investigate the efficacy of per os vitamin D3 (cholecalciferol) in treating fatigue among otherwise healthy persons with low serum 25-hydroxyvitamin D (25(OH)D) levels. We enrolled 120 individuals (mean age 29 ± 6 years, 53% women) presenting with fatigue and vitamin D deficiency (serum 25(OH)D < 20 μg/L). Participants were randomized to a single oral dose of 100,000 units of vitamin D or placebo. The primary endpoint was intra-individual change in the fatigue assessment scale (FAS) at 4 weeks after treatment.

Result

The mean age of the participants was 29 ± 6 years, 53% were women. Mean FA

SUBMITTER: Nowak A 

PROVIDER: S-EPMC5207540 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature