Loss of BOSS Causes Shortened Lifespan with Mitochondrial Dysfunction in Drosophila.

ABSTRACT: Aging is a universal process that causes deterioration in biological functions of an organism over its lifetime. There are many risk factors that are thought to contribute to aging rate, with disruption of metabolic homeostasis being one of the main factors that accelerates aging. Previously, we identified a new function for the putative G-protein-coupled receptor, Bride of sevenless (BOSS), in energy metabolism. Since maintaining metabolic homeostasis is a critical factor in aging, we investigated whether BOSS plays a role in the aging process. Here, we show that BOSS affects lifespan regulation. boss null mutants exhibit shortened lifespans, and their locomotor performance and gut lipase activity-two age-sensitive markers-are diminished and similar to those of aged control flies. Reactiv

SUBMITTER: Kohyama-Koganeya A 

PROVIDER: S-EPMC5207625 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature