Iron Status in Attention-Deficit/Hyperactivity Disorder: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Attention-deficit/hyperactivity disorder (ADHD) is one of the most common psychiatric disorders in children. However, the pathogenesis of ADHD remains unclear. Iron, an important trace element, is implicated in brain function and dopaminergic activity. Recent studies have investigated the association between iron deficiency and ADHD, but the results are inconsistent.

Methods

A systemic search of MEDLINE, EMBASE, Web of Science and Cochrane Library databases was supplemented by manual searches of references of key retrieved articles. Study quality was evaluated using the Newcastle-Ottawa Scale. The standardised mean difference (SMD) and 95% confidence intervals (CIs) were calculated using a random-effects model. H2 and I2 were used to evaluate the heterogeneity, an

SUBMITTER: Wang Y 

PROVIDER: S-EPMC5207676 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature