Role of Autoregulation and Relative Synthesis of Operon Partners in Alternative Sigma Factor Networks.

ABSTRACT: Despite the central role of alternative sigma factors in bacterial stress response and virulence their regulation remains incompletely understood. Here we investigate one of the best-studied examples of alternative sigma factors: the σB network that controls the general stress response of Bacillus subtilis to uncover widely relevant general design principles that describe the structure-function relationship of alternative sigma factor regulatory networks. We show that the relative stoichiometry of the synthesis rates of σB, its anti-sigma factor RsbW and the anti-anti-sigma factor RsbV plays a critical role in shaping the network behavior by forcing the σB network to function as an ultrasensitive negative feedback loop. We further demonstrate how this negative feedback regulation insulates

SUBMITTER: Narula J 

PROVIDER: S-EPMC5207722 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature