Network Centrality Analysis in Fungi Reveals Complex Regulation of Lost and Gained Genes.

ABSTRACT: Gene gain and loss shape both proteomes and the networks they form. The increasing availability of closely related sequenced genomes and of genome-wide network data should enable a better understanding of the evolutionary forces driving gene gain, gene loss and evolutionary network rewiring. Using orthology mappings across 23 ascomycete fungi genomes, we identified proteins that were lost, gained or universally conserved across the tree, enabling us to compare genes across all stages of their life-cycle. Based on a collection of genome-wide network and gene expression datasets from baker's yeast, as well as a few from fission yeast, we found that gene loss is more strongly associated with network and expression features of closely related species than that of distant species, consistent wi

SUBMITTER: Coulombe-Huntington J 

PROVIDER: S-EPMC5207763 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature