Forebrain depletion of Rheb GTPase elicits spatial memory deficits in mice.

ABSTRACT: The precise molecular and cellular events responsible for age-dependent cognitive dysfunctions remain unclear. We report that Rheb (ras homolog enriched in brain) GTPase, an activator of mammalian target of rapamycin (mTOR), regulates memory functions in mice. Conditional depletion of Rheb selectively in the forebrain of mice obtained from crossing Rheb^f/f and CamKII^Cre results in spontaneous signs of age-related memory loss, that is, spatial memory deficits (T-maze, Morris water maze) without affecting locomotor (open-field test), anxiety-like (elevated plus maze), or contextual fear conditioning functions. Partial depletion of Rheb in forebrain was sufficient to elicit memory defects with little effect on the neuronal size, cortical thickness, or mammalian target of

SUBMITTER: Shahani N 

PROVIDER: S-EPMC5209246 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature