Design of Hydrated Porphyrin-Phospholipid Bilayers with Enhanced Magnetic Resonance Contrast.

ABSTRACT: Computer simulations are used to design more hydrated bilayers, formed from amine-modified porphyrin-phospholipids (PoPs). Experiments confirm that the new constructs give rise to bilayers with greater water content. When chelated with manganese, amine-modified PoPs provide improved contrast for magnetic resonance and are safely used for imaging in vivo.

SUBMITTER: Shao S 

PROVIDER: S-EPMC5209247 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature