Dominant Transmission Observed in Adolescents and Families With Orthostatic Intolerance.

ABSTRACT:

Background

Orthostatic intolerance is typically thought to be sporadic and attributed to cerebral autonomic dysfunction. We sought to identify families with inherited autonomic dysfunction manifest as symptomatic orthostatic intolerance to characterize mode of inheritance and clinical features.

Methods

Sixteen families with two or more first- or second-degree relatives with autonomic dysfunction and orthostatic intolerance were enrolled. A clinical diagnosis of autonomic dysfunction defined by symptomatic orthostatic intolerance diagnosed by head-up tilt table testing was confirmed for each proband. Clinical features and evaluation were obtained from each proband using a standardized intake questionnaire, and family history information was obtained from probands and availabl

SUBMITTER: Posey JE 

PROVIDER: S-EPMC5209259 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature