A longitudinal study of serum insulin and insulin resistance as predictors of weight and body fat gain in African American and Caucasian children.

ABSTRACT:

Background

The influence of insulin and insulin resistance (IR) on children's weight and fat gain is unclear.

Objective

To evaluate insulin and IR as predictors of weight and body fat gain in children at high risk for adult obesity. We hypothesized that baseline IR would be positively associated with follow-up body mass index (BMI) and fat mass.

Subjects/methods

Two hundred and forty-nine healthy African American and Caucasian children aged 6-12 years at high risk for adult obesity because of early-onset childhood overweight and/or parental overweight were followed for up to 15 years with repeated BMI and fat mass measurements. We examined baseline serum insulin and homeostasis model of assessment-IR (HOMA-IR) as predictors of follow-up BMI Z-score and fat mass by dua

SUBMITTER: Sedaka NM 

PROVIDER: S-EPMC5209266 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature