An epigenome-wide study of body mass index and DNA methylation in blood using participants from the Sister Study cohort.

ABSTRACT:

Background/objectives

The relationship between obesity and chronic disease risk is well-established; the underlying biological mechanisms driving this risk increase may include obesity-related epigenetic modifications. To explore this hypothesis, we conducted a genome-wide analysis of DNA methylation and body mass index (BMI) using data from a subset of women in the Sister Study.

Subjects/methods

The Sister Study is a cohort of 50 884 US women who had a sister with breast cancer but were free of breast cancer themselves at enrollment. Study participants completed examinations which included measurements of height and weight, and provided blood samples. Blood DNA methylation data generated with the Illumina Infinium HumanMethylation27 BeadChip array covering 27,589 CpG sites

SUBMITTER: Wilson LE 

PROVIDER: S-EPMC5209267 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature