Weight loss surgery in adolescents corrects high-density lipoprotein subspecies and their function.

ABSTRACT:

Background/objective

Youth with obesity have an altered high-density lipoprotein (HDL) subspecies profile characterized by depletion of large apoE-rich HDL particles and an enrichment of small HDL particles. The goal of this study was to test the hypothesis that this atherogenic HDL profile is reversible and that HDL function would improve with metabolic surgery.

Methods

Serum samples from adolescent males with severe obesity mean±s.d. age of 17.4±1.6 years were studied at baseline and 1 year following vertical sleeve gastrectomy (VSG). HDL subspecies and HDL function were evaluated pre and post VSG using paired t-tests. A lean group of adolescents was included as a reference group.

Results

After VSG, body mass index decreased by 32% and insulin resistance as estimate

SUBMITTER: Davidson WS 

PROVIDER: S-EPMC5209276 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature