Weight change in the management of youth-onset type 2 diabetes: the TODAY clinical trial experience.

ABSTRACT:

Background

The Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) clinical trial documented that metformin plus rosiglitazone, but not metformin plus lifestyle intervention, provided superior durability of glycemic control relative to metformin monotherapy.

Objectives

We examined weight changes among TODAY participants that completed at least 6 months of treatment, evaluated predictors of lifestyle outcome, and examined whether weight changes were related to cardiometabolic outcomes across treatment arms.

Methods

The 595 youth with type 2 diabetes, (85.1% of randomized participants aged 11-17 years) completed assessments of weight-related and cardiometabolic measures at months 0, 6, 12 and 24. Repeated measures models were used to investigate assoc

SUBMITTER: Marcus MD 

PROVIDER: S-EPMC5209292 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature