Knockout of Lysosomal Enzyme-Targeting Gene Causes Abnormalities in Mouse Pup Isolation Calls.

ABSTRACT: Humans lacking a working copy of the GNPTAB gene suffer from the metabolic disease Mucolipidosis type II (MLII). MLII symptoms include mental retardation, skeletal deformities and cartilage defects as well as a speech delay with most subjects unable to utter single words (Otomo et al., 2009; Cathey et al., 2010; Leroy et al., 2012). Here we asked whether mice lacking a copy of Gnptab gene exhibited vocal abnormities. We recorded ultrasonic vocalizations from 5 to 8 day old mice separated from their mother and littermates. Although Gnptab^-/- pups emitted a similar number of calls, several features of the calls were different from their wild type littermates. Gnptab^-/- mice showed a decrease in the length of calls, an increase in the intra-bout paus

SUBMITTER: Barnes TD 

PROVIDER: S-EPMC5209381 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature