Comparative Evaluation of Three TSPO PET Radiotracers in a LPS-Induced Model of Mild Neuroinflammation in Rats.

ABSTRACT:

Purpose

Over the past 20 years, neuroinflammation (NI) has increasingly been recognised as having an important role in  many neurodegenerative diseases, including Alzheimer's disease. As such, being able to image NI non-invasively in patients is critical to monitor pathological processes and potential therapies targeting neuroinflammation. The translocator protein (TSPO) has proven a reliable NI biomarker for positron emission tomography (PET) imaging. However, if TSPO imaging in acute conditions such as stroke provides strong and reliable signals, TSPO imaging in neurodegenerative diseases has proven more challenging. Here, we report results comparing the recently developed TSPO tracers [¹⁸F]GE-180 and [¹⁸F]DPA-714 with (R)-[¹¹C]PK11195 in a rodent

SUBMITTER: Sridharan S 

PROVIDER: S-EPMC5209405 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature