Current Safety Concerns with Human Papillomavirus Vaccine: A Cluster Analysis of Reports in VigiBase^®.

ABSTRACT:

Introduction

A number of safety signals-complex regional pain syndrome (CRPS), postural orthostatic tachycardia syndrome (POTS), and chronic fatigue syndrome (CFS)-have emerged with human papillomavirus (HPV) vaccines, which share a similar pattern of symptomatology. Previous signal evaluations and epidemiological studies have largely relied on traditional methodologies and signals have been considered individually.

Objective

The aim of this study was to explore global reporting patterns for HPV vaccine for subgroups of reports with similar adverse event (AE) profiles.

Methods

All individual case safety reports (reports) for HPV vaccines in VigiBase^® until 1 January 2015 were identified. A statistical cluster analysis algorithm was used to identify natural

SUBMITTER: Chandler RE 

PROVIDER: S-EPMC5209415 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature