Insulin resistance is associated with specific gut microbiota in appendix samples from morbidly obese patients.

ABSTRACT: Alterations in intestinal microbiota composition could promote a proinflammatory state in adipose tissue that is associated with obesity and insulin resistance. Our aim was to identify the gut microbiota associated with insulin resistance in appendix samples from morbidly obese patients classified in 2 groups, high (IR-MO) and low insulin-resistant (NIR-MO), and to determine the possible association between these gut microbiota and variables associated with insulin resistance and the expression of genes related to inflammation and macrophage infiltration in adipose tissue. Appendix samples were obtained during gastric bypass surgery and the microbiome composition was determined by 16S rRNA pyrosequencing and bioinformatics analysis by QIIME. The Chao and Shannon indices for each study grou

SUBMITTER: Moreno-Indias I 

PROVIDER: S-EPMC5209518 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature