Intercalative DNA binding of the marine anticancer drug variolin B.

ABSTRACT: Variolin B is a rare marine alkaloid that showed promising anti-cancer activity soon after its isolation. It acts as a cyclin-dependent kinase inhibitor, although the precise mechanism through which it exerts the cytotoxic effects is still unknown. The crystal structure of a variolin B bound to a DNA forming a pseudo-Holliday junction shows that this compound can also contribute, through intercalative binding, to either the formation or stabilization of multi-stranded DNA forms.

SUBMITTER: Canals A 

PROVIDER: S-EPMC5209663 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature