Placental transcriptome co-expression analysis reveals conserved regulatory programs across gestation.

ABSTRACT:

Background

Mammalian development in utero is absolutely dependent on proper placental development, which is ultimately regulated by the placental genome. The regulation of the placental genome can be directly studied by exploring the underlying organisation of the placental transcriptome through a systematic analysis of gene-wise co-expression relationships.

Results

In this study, we performed a comprehensive analysis of human placental co-expression using RNA sequencing and intergrated multiple transcriptome datasets spanning human gestation. We identified modules of co-expressed genes that are preserved across human gestation, and also identifed modules conserved in the mouse indicating conserved molecular networks involved in placental development and gene expression patt

SUBMITTER: Buckberry S 

PROVIDER: S-EPMC5209944 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature