Hypertensive Disorders of Pregnancy and Offspring Cardiac Structure and Function in Adolescence.

ABSTRACT: Fetal exposure to preeclampsia is associated with higher blood pressure and later risk of stroke. We aimed to investigate the associations of maternal preeclampsia, gestational hypertension, and maternal blood pressure change in pregnancy with offspring cardiac structure and function in adolescence. Using data from a prospective birth cohort study, we included offspring who underwent echocardiography (mean age, 17.7 years; SD, 0.3; N=1592). We examined whether hypertensive disorders of pregnancy were associated with offspring cardiac structure and systolic/diastolic function using linear regression. Using multilevel linear spline models (measurement occasions within women), we also investigated whether rate of maternal systolic/diastolic blood pressure change during pregnancy (weeks 8-18,

SUBMITTER: Timpka S 

PROVIDER: S-EPMC5210338 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature