Effects of cell-cycle-dependent expression on random fluctuations in protein levels.

ABSTRACT: Expression of many genes varies as a cell transitions through different cell-cycle stages. How coupling between stochastic expression and cell cycle impacts cell-to-cell variability (noise) in the level of protein is not well understood. We analyse a model where a stable protein is synthesized in random bursts, and the frequency with which bursts occur varies within the cell cycle. Formulae quantifying the extent of fluctuations in the protein copy number are derived and decomposed into components arising from the cell cycle and stochastic processes. The latter stochastic component represents contributions from bursty expression and errors incurred during partitioning of molecules between daughter cells. These formulae reveal an interesting trade-off: cell-cycle dependencies that amplify t

SUBMITTER: Soltani M 

PROVIDER: S-EPMC5210684 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature