Interlocus nonrandom association of polymorphisms in Drosophila chemoreceptor genes.

ABSTRACT: Some forms of multilocus selection with epistasis, such as truncation selection, can effectively reduce the mutation load [Kondrashov, A. S. (1988) Nature 336, 435-440]. Many quantitative characters, including complex genetic diseases, are likely to be subject to these types of selection. However, direct measurement of selection in natural populations is difficult and the effect of epistasis on within-species variations remains unclear. Epistatic interaction in the fitness effect can generate linkage disequilibrium (LD). Therefore, we may detect the action of natural selection from its amount and pattern. Here, we report a large number of interlocus nonrandom associations between polymorphisms in 98 Drosophila chemoreceptor genes. LD was examined in two fly samples collected at the same lo

SUBMITTER: Takano-Shimizu T 

PROVIDER: S-EPMC521131 | biostudies-literature | 2004 Sep

REPOSITORIES: biostudies-literature