An embedded network approach for scale-up of fluctuation-driven systems with preservation of spike information.

ABSTRACT: To address computational "scale-up" issues in modeling large regions of the cortex, many coarse-graining procedures have been invoked to obtain effective descriptions of neuronal network dynamics. However, because of local averaging in space and time, these methods do not contain detailed spike information and, thus, cannot be used to investigate, e.g., cortical mechanisms that are encoded through detailed spike-timing statistics. To retain high-order statistical information of spikes, we develop a hybrid theoretical framework that embeds a subnetwork of point neurons within, and fully interacting with, a coarse-grained network of dynamical background. We use a newly developed kinetic theory for the description of the coarse-grained background, in combination with a Poisson spike reconstru

SUBMITTER: Cai D 

PROVIDER: S-EPMC521148 | biostudies-literature | 2004 Sep

REPOSITORIES: biostudies-literature