Irreversible Electroporation of the Pancreas Using Parallel Plate Electrodes in a Porcine Model: A Feasibility Study.

ABSTRACT:

Background

Irreversible electroporation (IRE) with needle electrodes is being explored as treatment option in locally advanced pancreatic cancer. Several studies have shown promising results with IRE needles, positioned around the tumor to achieve tumor ablation. Disadvantages are the technical difficulties for needle placement, the time needed to achieve tumor ablation, the risk of needle track seeding and most important the possible occurrence of postoperative pancreatic fistula via the needle tracks. The aim of this experimental study was to evaluate the feasibility of a new IRE-technique using two parallel plate electrodes, in a porcine model.

Methods

Twelve healthy pigs underwent laparotomy. The pancreas was mobilized to enable positioning of the paddles. A standard mon

SUBMITTER: Rombouts SJ 

PROVIDER: S-EPMC5213381 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature