Tumor Expression of Vitamin D Receptor and Breast Cancer Histopathological Characteristics and Prognosis.

ABSTRACT:

Purpose

Our previous work has shown low serum 25-hydroxyvitamin D concentrations in association with aggressive breast cancer subtypes. Vitamin D receptor (VDR) is central for vitamin D-mediated transcription regulation. Few studies have examined breast VDR expression with tumor characteristics or patient survival.

Experimental design

VDR expression in breast tumor tissue microarrays was determined by immunohistochemistry in 1,114 female patients as low, moderate, and strong expression based on an immunoreactive score, and examined with histopathologic tumor characteristics and survival outcomes including progression-free survival, breast cancer-specific survival, and overall survival.

Results

A majority (58%) of breast tumors showed moderate or strong VDR expression.

SUBMITTER: Al-Azhri J 

PROVIDER: S-EPMC5213876 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature