Trial by Dutch laboratories for evaluation of non-invasive prenatal testing. Part II-women's perspectives.

ABSTRACT:

Objective

To evaluate preferences and decision-making among high-risk pregnant women offered a choice between Non-Invasive Prenatal Testing (NIPT), invasive testing or no further testing.

Methods

Nationwide implementation study (TRIDENT) offering NIPT as contingent screening test for women at increased risk for fetal aneuploidy based on first-trimester combined testing (>1:200) or medical history. A questionnaire was completed after counseling assessing knowledge, attitudes and participation following the Multidimensional Measure of Informed Choice.

Results

A total of 1091/1253 (87%) women completed the questionnaire. Of these, 1053 (96.5%) underwent NIPT, 37 (3.4%) invasive testing and 1 (0.1%) declined testing. 91.7% preferred NIPT because of test safety. Overall, 7

SUBMITTER: van Schendel RV 

PROVIDER: S-EPMC5213994 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature