Intratumoral natural killer cells show reduced effector and cytolytic properties and control the differentiation of effector Th1 cells.

ABSTRACT: Natural killer (NK) cells are known to have effector and cytolytic properties to kill virus infected or tumor cells spontaneously. Due to these properties, NK cells have been used as an adoptive cellular therapy to control tumor growth in various clinical trials but have shown limited clinical benefits. This indicates that our knowledge about phenotypic and functional differences in NK cells within the tumor microenvironment and secondary lymphoid tissues is incomplete. In this work, we report that B16F10 cell-induced melanoma recruits the CD11b⁺CD27⁺ subset of NK cells at a very early stage during tumor progression. These intratumoral NK cells showed increased expression of CD69, reduced inhibitory receptor KLRG1, and decreased proliferative ability. As compared to s

SUBMITTER: Paul S 

PROVIDER: S-EPMC5214058 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature