Dietary Emulsifier-Induced Low-Grade Inflammation Promotes Colon Carcinogenesis.

ABSTRACT: The increased risks conferred by inflammatory bowel disease (IBD) to the development of colorectal cancer gave rise to the term "colitis-associated cancer" and the concept that inflammation promotes colon tumorigenesis. A condition more common than IBD is low-grade inflammation, which correlates with altered gut microbiota composition and metabolic syndrome, both present in many cases of colorectal cancer. Recent findings suggest that low-grade inflammation in the intestine is promoted by consumption of dietary emulsifiers, a ubiquitous component of processed foods, which alter the composition of gut microbiota. Here, we demonstrate in a preclinical model of colitis-induced colorectal cancer that regular consumption of dietary emulsifiers, carboxymethylcellulose or polysorbate-80, exacerba

SUBMITTER: Viennois E 

PROVIDER: S-EPMC5214513 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature