The receptor for advanced glycation end products impairs collateral formation in both diabetic and non-diabetic mice.

ABSTRACT: Diabetics often have poor perfusion in their limbs as a result of peripheral artery disease and an impaired ability to generate collateral vessels. The receptor for advanced glycation end products (RAGE) is one protein that is thought to play a detrimental role in collateral development in diabetics due to increased levels of advanced glycation end products (AGE), one of its ligands, in diabetes. Thus, the aim of this study was to investigate the role of RAGE in both diabetic and non-diabetic settings in a model of collateral formation in mice. Streptozotocin was used to induce diabetes in both wild type and RAGE knockout mice. Increased levels of the AGE, N^ɛ-(carboxymethyl) lysine (CML), were confirmed via an ELISA. A hindlimb ischemia model, in which the femoral artery is liga

SUBMITTER: Hansen LM 

PROVIDER: S-EPMC5214531 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature