Reduced hippocampus volume and memory performance in bipolar disorder patients carrying the BDNF val66met met allele.

ABSTRACT:

Background

Previous studies investigated the impact of brain-derived neurotrophic factor (BDNF) val66met (rs6265) on hippocampus volumes and neurocognition in bipolar disorders (BD), but the results were not consistent. This study aimed to investigate the effect of BDNF polymorphism on hippocampus volumes and memory performance in well-characterized adult populations diagnosed with type I BD (BD-I) and major depressive disorder (MDD) compared with healthy controls (HC).

Methods

48 BD-I patients, 33 MDD patients and 60 HC were genotyped for BDNF rs6265 using DNA isolated from white blood cells. Individuals with val/met and met/met genotypes were grouped as met carriers and compared to those with the val/val. Brain segmentations were obtained from structural magnetic resonance

SUBMITTER: Cao B 

PROVIDER: S-EPMC5214589 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature