IFITM1 targets HIV-1 latently infected cells for antibody-dependent cytolysis.

ABSTRACT: HIV-1 persistence in latent reservoirs during antiretroviral therapy (ART) is the main obstacle to virus eradication. To date, there is no marker that adequately identifies latently infected CD4⁺ T cells in vivo. Using a well-established ex vivo model, we generated latently infected CD4⁺ T cells and identified interferon-induced transmembrane protein 1 (IFITM1), a transmembrane antiviral factor, as being overexpressed in latently infected cells. By targeting IFITM1, we showed the efficient and specific killing of a latently infected cell line and CD4⁺ T cells from ART-suppressed patients through antibody-dependent cytolysis. We hypothesize that IFITM1 could mark natural reservoirs, identifying an immune target for killing of latently infected cells. These n

SUBMITTER: Raposo RAS 

PROVIDER: S-EPMC5214598 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature