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Regulation of NKG2D⁺CD8⁺ T-cell-mediated antitumor immune surveillance: Identification of a novel CD28 activation-mediated, STAT3 phosphorylation-dependent mechanism.

ABSTRACT: The natural killer (NK) group 2D (NKG2D) receptor, which displays on mouse and human NK cells, activates CD8⁺ T cells and small subsets of other T cells. NKG2D⁺CD8⁺ T cells play critical roles in both innate and adaptive immunity upon engagement with NKG2D ligands to eliminate tumor and infected cells. Despite the important role of NKG2D⁺CD8⁺ T cells in immune surveillance, the mechanisms of how NKG2D expression on CD8⁺ T cells is regulated remain poorly defined. We treated mouse and human CD8⁺ T cells with CD80 recombinant protein, plus a pharmacologic model with small molecular inhibitors to determine which signaling pathway leads to NKG2D regulation on CD8⁺T cells. This study revealed that CD28 activ

SUBMITTER: Hu J

PROVIDER: S-EPMC5214668 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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Regulation of NKG2D⁺CD8⁺ T-cell-mediated antitumor immune surveillance: Identification of a novel CD28 activation-mediated, STAT3 phosphorylation-dependent mechanism.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Regulation of NKG2D+CD8+ T-cell-mediated antitumor immune surveillance: Identification of a novel CD28 activation-mediated, STAT3 phosphorylation-dependent mechanism.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Regulation of NKG2D⁺CD8⁺ T-cell-mediated antitumor immune surveillance: Identification of a novel CD28 activation-mediated, STAT3 phosphorylation-dependent mechanism.