Non-directed aromatic C-H amination: catalytic and mechanistic studies enabled by Pd catalyst and reagent design.

ABSTRACT: This manuscript describes the systematic development of pyridine-type ligands, which promote the Pd catalyzed, non-directed amination of benzene in combination with novel, hydroxylamine-based electrophilic amination reagents. DFT calculations and mechanistic experiments provide insights into the factors influencing the arene C-H amination protocol.

SUBMITTER: Bandara HM 

PROVIDER: S-EPMC5215025 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature