Development and Progression of Interstitial Lung Abnormalities in the Framingham Heart Study.

ABSTRACT:

Rationale

The relationship between the development and/or progression of interstitial lung abnormalities (ILA) and clinical outcomes has not been previously investigated.

Objectives

To determine the risk factors for, and the clinical consequences of, having ILA progression in participants from the Framingham Heart Study.

Methods

ILA were assessed in 1,867 participants who had serial chest computed tomography (CT) scans approximately 6 years apart. Mixed effect regression (and Cox) models were used to assess the association between ILA progression and pulmonary function decline (and mortality).

Measurements and main results

During the follow-up period 660 (35%) participants did not have ILA on either CT scan, 37 (2%) had stable to improving ILA, and 118 (6%) had

SUBMITTER: Araki T 

PROVIDER: S-EPMC5215030 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature