N-Acetyltransferase 2 Genotypes Are Associated With Diisocyanate-Induced Asthma.

ABSTRACT:

Objective

To investigate whether genetic variants of N-acetyltransferase (NAT) genes are associated with diisocyanate asthma (DA).

Methods

The study population consisted of 354 diisocyanate-exposed workers. Genotyping was performed using a 5'-nuclease polymerase chain reaction assay.

Results

The NAT2 rs2410556 and NAT2 rs4271002 variants were significantly associated with DA in the univariate analysis. In the first logistic regression model comparing DA+ and asymptomatic worker groups, the rs2410556 (P = 0.004) and rs4271002 (P < 0.001) single nucleotide polymorphisms and the genotype combination, NAT2 rs4271002*NAT1 rs11777998, showed associations with DA risk (P = 0.014). In the second model comparing DA+ and DA- groups, NAT2 rs4271002 variant and the combined genot

SUBMITTER: Yucesoy B 

PROVIDER: S-EPMC5215051 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature