AXL-Mediated Productive Infection of Human Endothelial Cells by Zika Virus.

ABSTRACT:

Rationale

The mosquito-borne Zika virus (ZIKV) is now recognized as a blood-borne pathogen, raising an important question about how the virus gets into human bloodstream. The imminent threat of the ZIKV epidemic to the global blood supply also demands novel therapeutics to stop virus transmission though transfusion.

Objective

We intend to characterize ZIKV tropism for human endothelial cells (ECs) and provide potential targets for intervention.

Methods and results

We conducted immunostaining, plaque assay, and quantitative reverse transcription-polymerase chain reaction of ZIKV RNA to evaluate the possible infection of ECs by ZIKV. Both the African and the South American ZIKV strains readily infect human umbilical vein endothelial cells and human ECs derived from aort

SUBMITTER: Liu S 

PROVIDER: S-EPMC5215127 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature