A systematic search strategy identifies cubilin as independent prognostic marker for renal cell carcinoma.

ABSTRACT:

Background

There is an unmet clinical need for better prognostic and diagnostic tools for renal cell carcinoma (RCC).

Methods

Human Protein Atlas data resources, including the transcriptomes and proteomes of normal and malignant human tissues, were searched for RCC-specific proteins and cubilin (CUBN) identified as a candidate. Patient tissue representing various cancer types was constructed into a tissue microarray (n = 940) and immunohistochemistry used to investigate the specificity of CUBN expression in RCC as compared to other cancers. Two independent RCC cohorts (n = 181; n = 114) were analyzed to further establish the sensitivity of CUBN as RCC-specific marker and to explore if the fraction of RCCs lacking CUBN expression could predict differences in patient survival.

SUBMITTER: Gremel G 

PROVIDER: S-EPMC5215231 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature