Characterization of a model of systemic inflammation in humans in vivo elicited by continuous infusion of endotoxin.

ABSTRACT: Investigating the systemic inflammatory response in patients with critical illness such as sepsis, trauma and burns is complicated due to uncertainties about the onset, duration and severity of the insult. Therefore, in vivo models of inflammation are essential to study the pathophysiology and to evaluate immunomodulatory therapies. Intravenous bolus administration of endotoxin to healthy volunteers is a well-established model of a short-lived systemic inflammatory response, characterized by increased plasma cytokine levels, flu-like symptoms and fever. In contrast, patients suffering from systemic inflammation are often exposed to inflammatory stimuli for an extended period of time. Therefore, continuous infusion of endotoxin may better reflect the kinetics of the inflammatory response en

SUBMITTER: Kiers D 

PROVIDER: S-EPMC5215288 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature